Although toxic in neonates and infants, it is generally recognized as safe by the FDA at concentrations up to 5% in adults. A-TOLUENOL, BENZENEMETHANOL, BENZYL ALCOHOL, BENZYLIC ALCOHOL, PHENYLCARBINOL, PHENYLMETHANOL, and PHENYLMETHYL ALCOHOL 46 4. Finally, benzyl alcohol 44 is used as a preservative in many topical preparations, such as antifungal and anti -inflammatory 45 .
It is also used as an active ingredient in local antiseptics.
Benzyl alcohol is an aqueous soluble preservative widely used in injectable pharmaceutical preparations as well as in cosmetic products. Benzyl alcohol is a naturally ocurring and synthetic ingredient used as solvent and preservative; has been associated with contact allergy. The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Its chief function in cosmetics is as a preservative, and it’s among the least sensitizing preservatives in use. Benzyl Alcohol Lotion, 5%, is the first head lice product approved by the FDA with benzyl alcohol as the active pharmaceutical ingredient. products. Benzyl Alcohol Lotion, 5%, received full market approval as a prescription medication, for use in patients 6 months of age and older. storage solution for chromatography media Traditionally, 20% ethanol has been the preservative of choice as a shipping and storage solution for chromatography media (resins).
Safety of Benzyl Alcohol in Children Many product contains benzyl alcohol as a preservative.
69 Formulations containing BENZYL ALCOHOL Decorative Cosmetics: Replumping Lip Primer by BRB International BV Replumping Lip Primer is a water-based lip primer balm with a plumping effect suitable to hydrate, moisturize, and eliminate lip wrinkles.
Benzyl alcohol is also present in medicinal products 43 administered intravenousl y (anti-cancer drugs, heparins, cardiovascular drugs). In a published study conducted in rats and rabbits, pregnant animals received heparin intravenously during organogenesis at a dose of 10,000 units/kg/day, approximately 1/6 the maximum human daily dose. Finally, benzyl alcohol 44 is used as a preservative in many topical preparations, such as antifungal and anti -inflammatory 45 . What are the safety concerns? High amounts of benzyl alcohol can impart a noticeable floral-like scent to products, as it is part of the fragrance makeup of some essential oils such as jasmine. Benzyl Alcohol is metabolized to Benzoic Acid, which reacts with glycine and excreted as hippuric acid in the human body. It also contains special labeling requirements, which outline … Benzyl alcohol is an ingredient that is used in cosmetics and personal care products as a fragrance component, preservative, solvent, and viscosity-decreasing agent.. Various studies show low rates of irritation and sensitization at 1% and 5% concentration which are within range of …
The list contains maximum concentration limits and other restrictions. High amounts of benzyl alcohol can impart a noticeable floral-like scent to products, as it is part of the fragrance makeup of some essential oils such as jasmine. Although benzyl alcohol toxicity has been recognized, the concentration necessary for antibacterial action appears to be much lower than the concentration that would be dangerous to adults. Karabit MS, Juneskans OT, Lundgren P. A successful kinetic approach to the screening of preservation efficacy of benzylalcohol--a neutral-type preservative--is described. preservative benzyl alcohol can cause serious adverse events and death when administered intravenously to neonates and infants [see Use in Specific Populations (8.4]. Studies on the evaluation of preservative efficacy--II.
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